P-694 Desogestrel did not affect Follicular Output Rate (FORT) during controlled ovarian stimulation for oocyte vitrification: prospective cohort study

Abstract Study question Does desogestrel an option for LH suppression during controlled ovarian stimulation oocyte vitrification? Summary answer This new did not affect FORT and, consequently, the number of collected oocytes vitrification. What is known already Traditionally, achieved by using a gonadotropin-releasing hormone (GnRH) analogue. However, improved cryopreservation techniques and freeze-all strategies are introducing concepts, including possibility progesterone instead GnRH analogues. Progesterone compounds currently wide-used freezing suppression. The use oral medroxyprogesterone was previously shown to effectively prevent surge, without impacting embryo development or pregnancy rates after frozen transfer. dydrogesterone with same purpose also effective. Desogestrel broadly accepted, has good tolerability low cost. design, size, duration A prospective cohort study performed period 2019-2021 75 patients submitted 173 women matched age as controls (patients IVF first time). Participants/materials, setting, methods Patients from control group used flexible antagonist suppression, in utilized mcg twice day (starting beginning gonadotropin hCG/agonist day). All received regimen (recombinant FSH). final maturation equal both groups hCG analogue agonist). primary endpoint antral follicle responsiveness follicle-stimulating hormone, measured FORT. Main results role chance Age [control group= 36 years (median 28-45); 23-43); p = 0.793; Mann Whitney U test], baseline count 8 (2-23); 9 (2-21); 0.741; test] anti-Mullerian 1.5 (0.05-7.95); 1.00 (0.01-16.00); 0.540; were similar between groups. length shorter [10.4±1.6 vs. 11.0±1.6; 0.044; t-student test,] those less than [2736 UI ± 745 2933 785; 0.047; test,]. Finally, Follicular Output Rate (FORT) 45%; 52%; 0.217; 6 (1-33); (1-20); 0.293; MII 5 (1-27); (1-19); 0.156, Limitations, reasons caution small sample size absence randomization main limitations our study. Since encouraging, randomized should be performed. Wider implications findings cheap easy vitrification, since same. scientific report showing Trial registration Not applicable